Almost three quarters of gene mutations occurred within the last 5 to 10 millennia of humans’ 200,000 years existence, and those of European descent have most of the harmful ones, an analysis of people in the U.S. showed.
Scanning the genes of children with inherited brain disorders pinpoints the precise cause more than a quarter of the time, often changing the diagnosis, according to one of the largest studies of child DNA sequencing.
Medical advances have made it increasingly common for older Americans such as Dick Cheney to receive heart transplants, extending their lives. The shift may make it more difficult for younger patients as aging Baby Boomers compete for available organs, top cardiologists say.
Exactly why James Markam is alive and well is a bit of a mystery. The octogenarian has lost four siblings to cancer, heart disease and emphysema, all before they reached the age of 62. Yet the retired airline executive recalls only one bout of sickness, culminating with a chest cold, 50 years ago.
Almost a decade after the U.S. human genome project was completed, scientists say they have mapped the underlying regulatory system that switches DNA on and off, potentially spurring a wave of new research into the molecular basis of complex diseases such as Type 1 diabetes.